Enter-Basket of Baskets trials

What is it?

This is an informational website developed within the DART – Building Data-Rich Clinical Trials project, funded by the European Union. It presents the Basket of Baskets (BoB) trial, a European adaptive basket trial led by Cancer Core Europe. Using a histology-agnostic design, the trial groups cancer patients by shared genetic or molecular mutations rather than tumour type, testing multiple targeted therapies across different cancers.
The study includes two components: i-Profiler (genomic profiling to identify actionable mutations) and i-Basket (treatment phase matching patients to therapies). The site also outlines ethical approval, informed consent, and European collaboration, providing clear guidance for patients, caregivers, and clinicians.

How can it be useful?

The i-ENTER platform supports informed decision-making for patients considering participation in adaptive basket trials. It provides a practical overview of mutation-driven recruitment, targeted treatment allocation, and multi-centre collaboration in precision oncology. For researchers and regulators, it demonstrates how innovative trial designs can be effectively communicated and implemented within European clinical research. As part of the toolbox, it serves as a real-world example of how the DART project translates complex adaptive design concepts into accessible, patient-centred resources that promote transparency and engagement in oncology trials.